Select an M-of-N threshold appropriate for your operational needs: 2-of-3 is common for small teams, while larger organizations may require 3-of-5 or higher thresholds with formal governance.
Distribute signers across roles and geographies to reduce collusion and single-point-of-failure risk. Document each signer's hardware wallet, backup status, and communication channel.
Test a small transaction and recovery drill before migrating significant holdings. Document onboarding and offboarding procedures for signers.
Improper multisig setup can permanently lock funds if quorum cannot be achieved; planning should include continuity scenarios for signer loss.